Word: coxing
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...been a painful 15 months both for people with arthritis and for the companies that make their painkilling drugs. The once high-flying anti-inflammatories known as cox-2 inhibitors nearly crashed and burned in September 2004, when Merck's popular Vioxx was pulled from the market after a study revealed it could raise the risk of heart attack and stroke. A competitor made by Pfizer, Bextra, was yanked some months later, leaving only Pfizer's Celebrex behind-and a new, required safety warning hasn't exactly done wonders for that drug's appeal. Celebrex sales are off more than...
...that Pfizer announced this week that it is going to try to settle the cox-2 safety question once and for all. Working with cardiologist Steven Nissen of the Cleveland Clinic, Pfizer has initiated a massive $100 million, four-year trial that will test the drug on 20,000 arthritis patients who are already at high risk for heart attack or stroke to determine what risk, if any, Celebrex actually poses...
...naproxen. They will also take aspirin, cholesterol-lowering drugs and other medications appropriate for heart patients, as well as a drug to prevent stomach bleeding, which all three of the painkillers may cause. The four-year study should be sufficient time to reveal what risk, if any, the cox-2s pose, but it could end sooner if one of the medications reveals itself as just too dangerous...
...outweighed by the benefits. ?Pfizer is fulfilling the commitment it made over a year ago to study Celebrex in this patient population," says Pfizer spokesman Bryant Haskins. When it comes to getting the most reliable data, it's that population-people who are part of the real group the cox-2s are thought to endanger-that produces the best results...
...current star of “Extras”) were regular contributors.You also probably haven’t heard of Daisy Donovan, another Brit who got her start as a presenter on the “Eleven O’Clock Show.” Well, thanks to Courtney Cox and David Arquette, she’s got a show all her own on TBS.It’s a sort of reality-comedy hybrid. Daisy is traveling from New York to L.A., and trying a series of careers and experiences along the way, the first being that...