Word: coxing
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Heart attack, stroke or cancer. Take your pick. That was the choice I was being offered, or so it seemed. I'm one of hundreds of patients who were participating in clinical trials to investigate whether COX-2 inhibitors such as Celebrex and Vioxx, commonly used as anti-inflammatory drugs, are also effective in fighting or preventing cancer. But the trials were halted last year after reports that the risk of heart attack or stroke doubled among a group of Vioxx users. Vioxx was summarily yanked from the market and the tort lawyers immediately canceled lunch. Celebrex was also implicated...
Although most of the COX-2 cancer trials eventually resumed, some of the original subjects dropped out, and you can't blame them. There's something screwy about the way the whole COX-2 debacle unfolded. Drugs linked to a relatively small risk of heart attack got pulled off the shelves without apparent concern for the cancer patients whose lives the same drugs might save...
Ironically, the trial that exposed the heart risks of COX-2 inhibitors was a cancer experiment, designed to test whether Vioxx or Celebrex could prevent the recurrence of colon cancer. It was halted before any conclusion could be reached. The situation was even more frustrating for patients in a second trial. There, scientists did indeed find a lower recurrence of colon tumors in patients taking Vioxx. "There was a reduction in adenoma recurrence," notes the study's lead author, Dr. Robert Bresalier of MD Anderson Cancer Center. "How that balances with the potential risk remains to be seen...
...many pockets as her trusty military knapsack, she decided to make one. Then she sold one on eBay. After hand sewing 500 bags, she decided last year to find a manufacturer and sell wholesale to baby boutiques. She garnered celebrity clients like Cate Blanchett, Gwyneth Paltrow and Courteney Cox, and she projects $100,000 in sales this year. "I seriously don't want it to get too large," she says. "I always wanted to be a stay-at-home mom. I didn't want to go back to work and travel all over the place...
...that no matter how well qualified a candidate is, he can't be a judge if he shares President Reagan's opinion of abortion or affirmative action." The escalation of partisan infighting has begun to worry close observers who take neither side in the fray. Constitutional Scholar Archibald Cox, who was fired as special Watergate prosecutor by President Nixon, fears that politicizing the appointment process endangers something more crucial to the nation than either party's social agenda. He warns, "The idea of judicial independence may be at risk." Neither side could welcome such a result. The intent...