Word: cr
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Those drugs haven't been perfected yet, but Sinclair and other researchers are making progress by trying to understand at the molecular level what it is about CR that seems to slow aging. Sinclair has found, for example, that resveratrol, a chemical found in red wine, increases life-spans of yeast and fruit flies. It works by amplifying the action of a molecule called SIRT1, which is present in all life forms and is produced in response to stress. "It's like a cell's 911 center," says Sinclair, and resveratrol is like a false alarm...
That fits with one of the leading theories about why CR works in the first place: starving the body puts it under mild, constant stress, priming it to resist the more severe stresses that make cells age--a sort of self-vaccination against decline. "With resveratrol," says Sinclair, "we're tricking the body into thinking it's not getting enough calories." If he can create a form of resveratrol that's easily absorbed by human cells and can demonstrate that it works without dangerous side effects, Sinclair may eventually come up with what amounts to an antiaging pill...
...University of Wisconsin at Madison, gerontologist Richard Weindruch studies deprivation, like Sinclair, but has a different idea about why calorie restriction works. He has been comparing calorie-restricted rhesus monkeys with unrestricted ones and has found striking differences. The CR monkeys have shown no evidence of diabetes, for example, while it affects about half of normal monkeys. Only four of his CR monkeys, moreover, have died from age-related diseases--half the rate of the control group. He believes the explanation lies in the complex activities of fat cells. The CR monkeys have much less body fat, and that--just...
...meantime, members of the CR movement are proceeding with their personal experiments in consumption. Although early CR advocates tried extreme diets, hoping to live to 120 or beyond, most current practitioners take a more moderate approach and have the more modest goal of staving off illness. For the past five years, Andrea Tiktin-Fanti, 61, of Uhrichsville, Ohio, has been adhering to a 1,200-calorie-a-day diet--about half what U.S. women typically eat. Diabetes killed both her parents in their 60s, but her diabetes is under control, thanks to her Spartan diet. "If I live...
...engine, with optional all-wheel drive and a neat, flexible seating configuration: the rear seats slide on an 8-in. track for extra legroom or more cargo space. Starting at $21,560, the Equinox stacks up competitively against such rivals as the Honda CR-V and Toyota RAV4. Volvo, meanwhile, just launched an all-new wagon, the V50, featuring the automaker's typical sturdiness and premium safety. The burlier Volvo XC90 (with a V-8 on the way) also earns high marks for crashworthiness, with an enhanced crush-resistant roof, a roll-stability system and inflatable side curtains. Volvo...