Word: crixivan
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Dates: during 1990-1999
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TORONTO: Could patients be developing an immunity to parts of the chemical cocktail that has proven so effective in fighting HIV? The announcement to this effect by Dr. Steven Deeks, a University of San Francisco AIDS researcher, that people might be developing an immunity to the protease inhibitors Crixivan and Norvir has left many questioning whether the highly-expensive treatment would remain worthwhile. A study of 136 HIV-positive people who started using the inhibitors in March of 1996 showed that within a year the virus had returned to detectable levels in about 53 percent...
...strong research efforts over the past decade are beginning to pay off. Crixivan, a Merck product, was one-third of the promising "drug cocktail" released last year to treat AIDS. Merck also released Fosamax, a treatment for osteoporosis, which affects one-third of all women over 60. This year, Merck has already introduced nine drug products, Gilmartin said...
What he got was something else. In March, his doctor put him on a third drug, Crixivan, one of the new protease inhibitors. Up to this point, Schwartz's story had been like most in the epidemic, none of them very encouraging. But 1996 reinvented the genre and put at its center the AIDS patient who bounces back on the three-drug cocktail. Over the past year--like a character plucked from a drama and dropped into what, exactly?-- Schwartz moved from one story to the other. His T cells are back above 500. His viral load, meaning the presence...
Merck & Co. will provide free Crixivan, an experimental AIDS medicine, to 1,400 people in the later stages of the disease. Recipients will be selected by a special lottery within the U.S. Last month Hoffman-La Roche Inc. created 2,280 slots for a similar lottery to receive the AIDS drug Invirase...