Word: crp
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Whooley's team studied the depressed group further. Researchers systematically adjusted for each potential risk factor to figure out whether it was mediating the link between depression and heart disease. Physiological factors, such as serotonin levels or CRP, for example, appeared not to have much impact. But when researchers adjusted for physical activity - that is, when they analyzed the data by assuming identical levels of exercise in both depressed and non-depressed patients - the difference in heart disease risk between the groups disappeared. Indeed, inactivity among the depressed patients gave them a 44% greater risk of having a heart event...
...results of the study not only shift the state of the evidence but also herald new guidelines for the prevention of heart disease and redefine the traditional at-risk population. Many people who, for example, lack outward signs of heart disease may have high CRP levels, which could put them at silent risk for heart attack or stroke. According to the study, published also in the New England Journal of Medicine, at least 250,000 heart attacks, or about 20% of the total heart attacks suffered per year in the U.S., may be prevented by controlling inflammation. Indeed, nearly half...
Although JUPITER (Justification for the Use of Statins in the Prevention: an Intervention Trial Evaluating Rosuvastatin) was designed to study inflammation, its findings also underscore the risk of high cholesterol. The study's statin group clearly benefited from reducing CRP, but they had also simultaneously lowered their LDL levels to nearly 50% below the government-prescribed target of 100 mg/dL. Experts say the JUPITER results may prompt serious rethinking of the current guidelines - an issue that health officials have already been debating in recent years. "I would not be surprised if, given these results, we determined that normal LDL should...
...causes heart attacks. How aggressive the inflammatory response is depends on a person's genes, diet, stress levels and even exposure to chronic infections such as gum disease. So, the more active the inflammatory response, the greater the chance of ruptured plaques and heart attack. In people with elevated CRP, that means the danger lies not so much in the number of plaques (measured by cholesterol) but in how likely they are to burst (measured by CRP...
...study suggests that screening all patients for CRP (a $10 test) as well as for cholesterol and blood pressure would not be unwise, or perhaps the test should be used for patients with indeterminate heart-disease risk, who may derive benefit from taking a statin. Longer-term trials are still needed, however, to show whether the benefits of statins outweigh their potential side effects - the drugs are relatively benign, but they are known in rare cases to cause debilitating side effects such as muscle weakness (which forced Bayer to pull its version off the market in 2001). There...