Word: crucially
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Dates: during 1990-1999
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Only three weeks into the season, the Crimson had already dropped two games-one a crucial league contest-and had already placed itself in a precarious wildcard situation come NCAA Tournament time...
However, the tide suddenly turned on the Crimson, finding itself tied 1-1 in games and facing a 13-5 deficit in the third game. Consumed with determination and persistence, the team came back and won the crucial third game...
...used ever since to funnel grants to groups dedicated to expanding Jewish settlements in the territories occupied by Israel after the 1967 war. His donations rose sharply after 1988, when officials in Hawaiian Gardens asked his foundation to take over a failing bingo hall that was a crucial source of local tax revenue. Within three years, the take of the nonprofit gaming operation had jumped to $33 million a year. Some of the proceeds went into city coffers and to charities, but much more made its way to the settlers. Moskowitz prefers to donate to specific projects rather than finance...
...first glance, these stories seem completely unrelated--three profoundly different disorders treated with three different drugs. Yet all three medications have one crucial element in common: they target the brain chemical serotonin. Though serotonin has been known to researchers for nearly a half-century, only in recent years have neuroscientists begun to understand how important this one substance is to the functioning of the human psyche. Serotonin, or the lack of it, has been implicated not only in depression, uncontrollable appetite and obsessive-compulsive disorder but also in autism, bulimia, social phobias, premenstrual syndrome, anxiety and panic, migraines, schizophrenia...
...would they? After all, other serotonin enhancers, such as Prozac, have never caused heart problems. There is a crucial difference, however, between Prozac and Redux-fenfluramine. The former, like the other SSRIS, keeps serotonin in circulation longer than it would otherwise be, thus helping the brain get the most out of its normal output. The latter do the same, but they also force nerve cells to boost the levels of serotonin that go into circulation. It is this unnatural bath of excess serotonin, some scientists theorize, that causes heart-valve defects and also triggers brain damage--in monkeys...