Word: culver
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Dates: during 1990-1999
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...creating a ring linking the areas outside Boston's downtown area, the Ring's supporters hope to break down the "tribalist" nature of Boston's neighborhoods, according to Bob Culver, a former T administrator who was one of the conference's organizers...
...Boston wasn't developed in spokes unconsciously," said Culver, calling the estranged communities "dysfunctional feifdoms...
...such loan went to IDB Communications Group, a telecommunications service company based in Culver City, California, whose $78 million line of credit was canceled by a group of banks. "I spent every waking hour for half a year on this issue," says IDB's chief financial officer, Ed Cheramy. "It was the worst experience of my life...
...work is based on the landmark experiment performed in 1990 by NIH Drs. W. French Anderson, Michael Blaese and Kenneth Culver on two Ohio girls, ages 4 and 9. Neither child was producing ADA, an enzyme that rids the bloodstream of harmful metabolic products. The absence of ADA can cause SCID by allowing toxic substances to accumulate and destroy immune-system cells. Both children had been kept alive by weekly injections of PEG-ADA, a costly synthetic enzyme, but neither was in good health...
Anderson, then at the NIH, with colleagues Dr. R. Michael Blaese and Dr. Kenneth Culver, extracted T cells from the little girl's blood and exposed them to a mouse-leukemia retrovirus that had been rendered harmless and endowed with a normal ADA gene. Invading the T cell, the retrovirus acted as a vector, depositing its genetic material, including the ADA gene, in the cell nucleus. After the re-engineered T cells were cultured, a process that produced billions of them, they were infused back into the child's bloodstream, where their new gene began producing the ADA enzyme...