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Anderson, then at the NIH, with colleagues Dr. R. Michael Blaese and Dr. Kenneth Culver, extracted T cells from the little girl's blood and exposed them to a mouse-leukemia retrovirus that had been rendered harmless and endowed with a normal ADA gene. Invading the T cell, the retrovirus acted as a vector, depositing its genetic material, including the ADA gene, in the cell nucleus. After the re-engineered T cells were cultured, a process that produced billions of them, they were infused back into the child's bloodstream, where their new gene began producing the ADA enzyme...

Author: /time Magazine | Title: Happy Birthday, Double Helix | 3/15/1993 | See Source »

...When I proposed this idea, people thought it was crazy," says Kenneth Culver, an oncology researcher at the National Cancer Institute. But it worked like a charm. In 11 of the 14 rats, the tumors disappeared completely. The results were so promising that an NIH watchdog committee has already okayed a similar test on humans. The risks are high. The researchers will, in effect, be putting mouse genes directly into human brains. But the payoff could be great. Scientists are now searching for other inoperable cancers that might succumb to what they are calling "molecular surgery...

Author: /time Magazine | Title: Scalpel! Laser! Retrovirus! | 6/22/1992 | See Source »

...what to think, for example, about the new area of litigious behavior that has blossomed and might be dubbed emotional tort law? Last March Julie Rems, 26, who is deaf, competed in the early rounds of a Miss America contest in Culver City, Calif. Though she was warned that Miss America rules precluded anyone assisting her onstage, Rems nonetheless brought on an interpreter who helped her lip-read questions. Rems lost the contest and sued the pageant committee and others, charging violation of her civil rights as well as "embarrassment, humiliation and degradation." The case has not yet come...

Author: /time Magazine | Title: Exculpations Crybabies: Eternal Victims | 8/12/1991 | See Source »

...landmark experiment, led by Dr. W. French Anderson, a pioneering advocate of gene therapy, and Drs. R. Michael Blaese and Kenneth Culver, raised the curtain on what some experts believe will be a new era in medicine, when many previously incurable genetic diseases will be contained or even conquered. The long-term impact on society could be enormous. Up to 5% of the infants born in the U.S. are afflicted with often debilitating and sometimes fatal genetic diseases. In most cases, no effective treatment exists for these disorders, which are caused by one or more faulty or missing genes among...

Author: /time Magazine | Title: Medicine: Giant Step for Gene Therapy | 9/24/1990 | See Source »

With a wolf that eats a grandmother and a little girl who gets into mortal trouble by talking with a stranger, the classic fairy tale Little Red Riding Hood reeks of violence and veiled sexual terrors. But when a version of the story by Trina Schart Hyman reached Culver City, Calif., last fall, school officials thought they sniffed something really troubling: an implied endorsement of alcohol...

Author: /time Magazine | Title: California: Little Red Riding Hootch | 6/4/1990 | See Source »

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