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...addition to showing that the vaccine can prolong remission, Bendandi's trial attempted to solve the long-standing problem of quantifying the results of custom-made treatments. Advanced drug trials require a control group, one whose members share key characteristics with those in the experimental arm, but who receive a placebo or another treatment rather than the one under study. According to Bendandi, randomized testing of custom-made vaccines would be meaningless because each patient in the experimental arm receives a different treatment. So he set about proving efficacy in another way. "The course of the study design...
Bendandi's vaccine also faces challenges common to other customized treatments: it's expensive (an estimated $34,000 per patient), it's difficult to make, and not all pharmaceutical companies (which make profits by mass-producing drugs) are able - or willing - to take on the work of producing a different vaccine for every patient. But with three Phase III clinical trials for idiotype vaccines under way in the U.S., and several other types of custom treatments in development (on March 29, an fda advisory committee found "substantial evidence" that a prostate cancer vaccine is effective, increasing the likelihood...
Einstein's greatest intellectual stimulation came from a poor student who dined with his family once a week. It was an old Jewish custom to take in a needy religious scholar to share the Sabbath meal; the Einsteins modified the tradition by hosting instead a medical student on Thursdays. His name was Max Talmud, and he began his weekly visits when he was 21 and Einstein...
...which House “spirit” clumsily approximates is indeed a very natural and healthy phenomenon. One inherently feels affection for the soil on which he has been born and raised, where he and his neighbors have long known each other, reflect local peculiarities of speech and custom, and profess a common conception of the world. A home is something worthy of being proud—something distinctly one?...
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