Word: cyclosporin
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Dates: during 1990-1999
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Born with a malfunctioning liver, Benny underwent his first transplant at age 8. For five years, he took a drug called cyclosporin that prevented his body from rejecting the alien organ. When that medicine no longer worked, his doctors at Children's Hospital in Pittsburgh performed a second transplant in 1992 and started him on what was then an experimental treatment called FK506. Given his long experience, he was probably better prepared than most people for the pain and discomfort antirejection drugs can sometimes cause. He had already outlived most of the children he had met in the hospital while...
...those products, cyclosporin, had potential as a lifesaving drug, he says...
...work led to the creation of a new pharmaceutical company in Cambridge, Ariad Pharmaceuticals, which has continued work on the possible applications of cyclosporin...
Until now, the drug cyclosporin has prevented organ transplant rejection by blocking an enzyme involved in the creation of T cells. But extended treatment with cyclosporin leads to toxicity and suppresses the immune response, leaving a patient vulnerable to other diseases, according...
With the gene sequence of NFATp, "we may be able to create a drug specific to NFAT without the harmful effects of cyclosporin," said...