Word: cyclosporine
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Dates: during 1980-1989
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Using these engineering techniques, scientists hope to engineer a new line of antiviral agents to combat AIDS to supplement the engineered drug acyclovir already in use. Other synthetic drugs in use today include cyclosporin, a drug used in transplant patients and aspirin, Corey said...
...Professor of Surgery Gilbert H. Mudge, another heart transplant specialist, looked more favorably upon the operation. He emphasized that cyclosporin had yet to be tested in xenographs and there was a possibility of such transplants being successful. "I think it was a heroic attempt to save a life which would have inevitably died, and, although the operation was not a breakthrough, it did use a new technique [cyclo-porin] and therefore was reasonable...
...Cohn did offer some positive encouragement also. He says the new wonder immune-suppressions drug, cyclosporin, which was pioneered for use with heart transplants at the Harvard-affiliated Brigham and Women's Hospital (BWH) last year, had not yet been tested in cross-species transplantation and indicated that Bailey was going to attempt the operation. However, he says that the likelihood of success even with the new drug was minimal...
...much more than the theoretical potential of the transplant to extend the baby's life, it also involves presenting a true assessment of the process to the public, says Raphael H. Levey, chief of transplants surgery at BWH. "I'm not glad the operation was tried at this time. Cyclosporin is not the miracle drug it's cracked up to be and it's not good to create hype and give false hope to the public, while seeking undue publicity for an unjustified operation...
...Cyclosporin A was developed four years ago and has been used by a handful of hospitals since then. It was formally approved by the FDA in November, 1983, and has been credited with improved success rates in liver, kidney, and heart transplants...