Word: cystic
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...lungs from a 32-year-old victim of a car accident declared brain dead several hours earlier. Working swiftly, they excised the organs, chilled them to 45 degrees F and transported them across town to Johns Hopkins Hospital. Clinton House, 28, a refrigeration mechanic whose lungs were ravaged by cystic fibrosis, had been summoned from his home and was being wheeled into the operating room. He had waited a year for this moment. In a room ten yards away, doctors prepared John Couch, 38, of Yardley, Pa., who was suffering from advanced heart disease...
...House, the transplant was a last resort in a lifelong battle with cystic fibrosis. CF victims produce abnormally thick, sticky mucus and other secretions that block normal lung function and interfere with digestion. Babies born with CF used to die in early childhood, but today more than half reach their early 20s, thanks to a battery of drugs that control lung infections, aid digestion and limit secretions. Still, few survive beyond the age of 30. House's lungs were "just about gone," according to his father, and for three years he had used an oxygen tank while he installed...
...more than five years. Surgeons in England have demonstrated that the procedure can work well on CF patients. One woman there has survived for 20 months with a new heart and lungs. "She is living a reasonably normal life, working at a library," reports Biochemist Robert Beall of the Cystic Fibrosis Foundation in Bethesda, Md. Before surgery, he says, the woman "had to be carried from bed to bathtub." Especially encouraging is the fact that the woman's new lungs have not been affected by cystic fibrosis...
...Cystic fibrosis, cleft palate, muscular dystrophy, Alzheimer's disease, Huntington's chorea. The list of disorders that have been traced to a specific gene or gene region seems to grow on a weekly basis. The latest in this gene- of-the-week series: the discovery of a region on the X chromosome that is linked to manic depression, a mental disorder that affects as many as 2 million Americans. The finding, published in Nature by an American and Israeli research team, was based on studies of five families in Jerusalem. It marks the second time in three weeks that...
...enzymes that slice DNA in distinctive patterns; families with a history of a genetic disease will tend to have similar configurations, permitting scientists to zero in on the likeliest site of the offending gene. In recent weeks biologists have announced the discovery of RFLP distinctive patterns, or "markers," for cystic fibrosis, which afflicts about 30,000 Americans; cardiovascular disease susceptibility; polycystic kidney disease; and muscular dystrophy. Says Manuel Buchwald of the Hospital for Sick Children in Toronto, one of the co-discovers of the cystic fibrosis marker, "It's the first handle we have on the disease...