Word: cytoxan
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...Edwards' original cancer was diagnosed in the fall of 2004. The specifics of her treatment were not made public, but doctors say it's likely that, in addition to surgery and radiation, she's already received three of the most commonly used drugs - Adriamycin, Cytoxan and either Taxol or Taxotere. This potent regimen knocks out tumor cells and causes the familiar side effects of nausea and hair loss. If her original tumor was estrogen-sensitive - meaning growing in response to the hormone - then she is almost certainly taking an estrogen-blocking drug such as Tamoxifen. (See TIME's photo-essay...
...Browder, who was working full-time in Folkman's laboratory, began experimenting with non-standard treatment regimens that utilized a standard chemotherapy drug, Cytoxan. He eventually developed a treatment schedule that appeared to inhibit the regeneration of endothelial cells--the cells that line blood vessels--in test mice...
Younger women and those who have no estrogen receptors usually receive combinations of two to five chemotherapy agents, such as Cytoxan and methotrexate, over a period of four months to a year. Because these drugs target rapidly dividing cells, they not only destroy cancer cells but also cells in the hair follicles, the lining of the digestive tract and the bone marrow. That produces the dreaded side effects of chemo: hair loss, nausea and a decline in infection-fighting white blood cells. Premature menopause can be another consequence. Even this harsh treatment provides no guarantee of a cure, though...
Still, he and his doctors will have to remain vigilant. As added insurance against any recurrence of cancer, the Memorial team may offer him an experimental postoperative regimen of two new anticancer drugs, cis platinum and cytoxan. The objective: to kill any small clusters of cancerous cells that may have eluded the surgeon's scalpel...
There were as many dissents as there were theories, and since so few drugs cure viral infections, the very fact that potent anti-cancer drugs such as amethopterin (Methotrexate) and cyclophosphamide (Cytoxan) have cured massive cases of Burkitt's supermalignant tumor might seem to argue against a viral cause. But doctors now believe that what the drugs do is cure or relieve a viral-induced cancer, after the virus itself may have vanished. Thus they may give the body an opportunity to develop its own mechanisms to fight the cancer...
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