Word: d2
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Dates: during 2010-2019
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That is, the down-regulation of D2 receptors seems to turn normal desire into compulsion. In Kenny's study, the rats that had been given extended access to junk food for 40 days were later willing to continue seeking fatty foods at the risk of getting a painful electric shock to the feet. Limited-access and chow-only rats, however, were significantly put off by the threat of shock, and stayed away from the junk-food buffet...
...extended-access rats also showed a lowered level of a certain type of dopamine receptor in the brain, which is thought to contribute to pleasure-seeking behavior in humans. "Human cocaine addicts, people who are obese, alcoholics and heroin addicts also show a down-regulation of this dopamine D2 receptor," says David Shertleff, director of the division of basic neuroscience and behavioral research at the National Institute on Drug Abuse. "This system is geared toward motivating behavior normally, but what's happening here is, with chronic exposure to highly fatty and sweet manufactured food, you're actually getting...
...nearly enough of the campy talking owl Bubo from the original in this Clash. He makes an appearance here. But he was sort of like R2-D2 in the original one. You have to be careful with those little nods to the [original] audience. My nephew ain't going to get that. Mads Mikkelsen [(Draco)] didn't even get it. He didn't see the original, so he didn't know what...