Word: dale
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...Chester Dale Collection. Unlike the Frick and Bache collections, the great collection of French moderns assembled by knowing, tawny-haired Mrs. Chester Dale is not yet a public museum, but visitors are welcome within reason...
...book begins at Krebs' famous inn at Skaneatles, wanders to Lily Dale and Chautaqua, back to the Genesee country, and through the Bristol Hills. It follows an aimless route in the Rochester-Geneseo-Buffalo area, through to the Binghamton-Ithaca "Storm Country", "Down the Bear Path Road" of Central New York, up North to the Adirondacks, "Land of Frozen Flame." Hit and miss Mr. Carmer picks up local anecdotes, Indian superstitions, regional customs, scenic wonders, as he goes. It is a peculiar system of newsgathering he uses, here depending on what he sees and knows, here taking in the stories...
...Loewi discovered, Dr. Dale proved, that nervous impulses are the result of chemical action, not of electrical action as had formerly been supposed. Dr. Loewi might have had all the credit for this fundamental physiological work, if he were a more persistent researcher. A rich, energetic, glib man of medium height, he rises each morning at 5 o'clock, is in his laboratory exactly one hour later. Assistants do all the actual experimenting, for Dr. Loewi is remarkably clumsy, breaking almost everything he touches. This characteristic almost ruined Dr. Loewi's career a decade ago. He asserted that...
Seldom does Dr. Loewi spend more than two years on a subject. This inconstancy gave Sir Henry Dale, a big, diligent Englishman, opportunity to pioneer on his own with many a discovery in the chemistry of nerves. One of the subtlest products of nervous reactions is acetylcholine. Sir Henry found this evanescent substance, when isolated from the body, to be a colorless, odorless, crystalline powder. It causes capillaries and small arteries to dilate, thus lowering blood pressure and slowing the action of an overworking heart. It relaxes smooth muscles, thus relieving spasms of the bladder, ureters, uterus, intestines...
...lecturing to crowds of adulating scholars, he declared: "We do not have knowledge as to the therapeutical or pharmaceutical value of these researches. In the end they may throw light on causes rather than provide materials" (TIME, May 1, 1933). Nonetheless, acetylcholine, typical object of what Nobel Prizewinners Dale & Loewi call autopharmacology, is being used by enterprising doctors to treat arterial hypertension, inflamed arteries, gangrene of feet and hands, profuse sweating in tuberculosis, flaccidity of the bladder and intestines, bed sores...