Word: daleyisms
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...study, led by Dr. George Daley at the Children's Hospital in Boston, shows that Hwang's stem cell line contains the first human cells to be generated not through SCNT, but through a process called parthenogenesis, sometimes referred to as virgin birth, since development is sparked spontaneously from the egg alone, rather than from the union of egg and sperm. Parthenogenesis is always a risk during nuclear transfer, since the process involves extensive manipulation of the egg and its nucleus. At the time that Hwang's original paper was published in Science, stem cell researchers raised the possibility that...
...Daley's subsequent detailed genetic analysis of Hwang's stem cells have clearly established that they come from a single egg, putting to rest nagging questions about what, if anything, Hwang and his team had actually accomplished. It may not have been Hwang's original goal, but successful parthenogenesis is no small feat. If he had reported it in 2004, says Daley, stem cell research might be much further along today - and enjoying a better reputation. "If we had known three years ago that it was possible to generate stem cells through parthenogenesis, then we almost certainly would already have...
...find out whether Hwang's stem cells came from a single egg, Daley's team, which included leading researchers from England, Japan and Canada, conducted a whole-genome analysis of the DNA from Hwang's stem cell line. By analyzing tens of thousands of gene snippets on the cells' genomes, and comparing these signatures to those of the egg donor and of the skin cell donor, they were able to determine that the DNA fingerprint of the stem cells was consistent with that of the egg. "The genetic signature of a parthenote is very very obvious," says Daley. Because...
...time, eggs can be stimulated to divide on their own, compared to a 3%-5% development rate for nuclear transfer embryos - parthenogenesis still requires a steady supply of good quality human eggs. These are notoriously difficult to obtain, so the technique won't likely revolutionize medicine yet. But, suggests Daley, it could be used to help alleviate the organ-donation shortage in the U.S.: parthenogenetically created transplant tissues and organs can be banked and later matched on major immune markers to many different patients. It's not quite patient-specific medicine, but it is one step closer...
...Obama and Daley used the analogy to call for better gun-control laws. But this kind of call for outrage is only likely to resonate among those who are already outraged. "Cultural worldview," squishy as the concept may be, matters more than anything else when it comes to the most divisive issues - more than whether you are black or white, male or female, southern or eastern, urban or rural, conservative or liberal...