Word: dameshek
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Despite the conspicuousness of the warnings, said Dr. Dameshek, there is no evidence that prescribing physicians pay much heed. Yet Dr. Best was opposed to letting any Government agency decide what are the legitimate uses of Chloromycetin, arguing that this would infringe upon the doctor's right to treat his patient any way he thinks best. Dr. Dameshek reluctantly conceded that governmental restriction might be necessary. Whether the Government already has the right to impose restrictions is a matter of dispute within the Food and Drug Administration. So far, the faction which holds that FDA can only give information...
...again in hearings before the Senate Monopoly Subcommittee. Expert medical witnesses agreed that serious and fatal reactions to Chloromycetin are relatively rare. The University of Illinois' Dr. William R. Best suggested that only one patient out of 20,000 or even 100,000 might develop them. Dr. William Dameshek of Manhattan's Mount Sinai School of Medicine put the rate at about one in 10,000. Either way, it sounds few enough. But so many Americans took Chloromycetin that by 1964 the American Medical Association counted 298 U.S. cases of serious reaction, approximately half of them fatal...
...million in 1966) have been in domestic prescriptions. For what? Far too often, testified Dr. Best, for the common cold and similar viral infections (for which no drug is of any use), and against many bacterial infections for which safer drugs are just as effective. Dr. Dameshek added acne to the list of conditions for which Chloromycetin should not be prescribed...
...From this," Dr. Dameshek told the New York Academy of Sciences, "it is only a step to the thought that autoimmune reactions and certain types of leukemia might occur simultaneously, and in fact be one and the same thing." What makes this possibility especially intriguing is the fact that no "cause" of leukemia is known, though there is increasing evidence that it may be triggered by a virus...
...Dameshek has built a research bridge from the leukemias, or "blood cancers," to infectious mononucleosis, which he calls a "fascinating disease." It is, he says, at one and the same time an infection (presumably caused by a virus), a complex immune reaction, and an atypical, self-limiting form of leukemia. In "mono," several abnormal types of antibody are found at the times when the patient's lymph glands are overactive. Where the "not-self" or foreign proteins come from to start this process is not certain, but the likeliest source is the original virus, acting on lymph cells...