Word: dameshek
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...Know Thyself." Boston Hematologist Dr. William Dameshek of the Tufts-New England Medical Center pioneered the concept of autoimmune disease. It has long been accepted dogma that in ordinary healthy immune reactions the body is using a birthright of every living creature. This is a set of biochemical sentries which raise an alarm when the body is invaded by a foreign substance, especially a protein, so that the system can make antibody to neutralize the invader. "Normally," says Dr. Dameshek, "the body has safeguards so it can recognize 'self as opposed to 'not-self,' and it will...
...their own body constituents-which may be red cells, white cells or whole organs. For years we cried in the wilderness. We were called wild-eyed visionaries. Critics asserted that the human body should not, cannot and will not develop such a mechanism of self-destruction." By now Dr. Dameshek has far more supporters than detractors. Many of the supporters, Dr. Dameshek complains, accept his concept only if they can give it another name, "auto-allergy...
Fascinating Mono. In these three cases, it is easy enough to understand how the body can regard the escaping antigen-protein as "new" or "foreign," because it has been sequestered for years, perhaps since the fetal stage. Far more knotty are the questions that arise so often in Dr. Dameshek's practice as a hematologist. No less than 50% of all blood-destroying anemias acquired after infancy, he believes, are the results of autoimmune reactions. He is so confident of this that he abbreviates the disorders to AIHA-autoimmune hemolytic anemias...
...William Dameshek...
Although thousands of lives are saved each year through blood transfusions, errors in blood typing are not rare. Most of the errors are due to faulty technique and interpretation rather than mistaken identification. In the New England Journal of Medicine last fortnight, Dr. William Dameshek, Harvard blood specialist, remarked that he had seen five serious blood-transfusion accidents in Boston hospitals within the last two years. Blood typing is a delicate process, said he, and too often it is left to "poorly trained medical students, poorly trained interns or technicians. . . ." Dr. Dameshek urged State departments of health to jack...