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...smaller group of women - those who already have heart disease - the data suggests that statins can reduce heart-related deaths. But as Dr. Beatrice Golomb, a professor of medicine at the University of California, San Diego, says, they don't reduce deaths overall. "Any reduction in death from heart disease seen in the data has been completely offset by deaths from other causes," she says. Which raises the question: If statins do not help prolong women's lives, why are so many women taking them...
Slicing the Sex Data"There are millions of women on a drug with no known benefit and risks that are detrimental to their lifestyle - and no one is talking about it. Why?" asks Dr. Rita Redberg, a prominent cardiologist at the University of California, San Francisco...
...researchers say the field has not taken the next step: tailoring treatments according to gender-specific data. In many cases, notably with statins, they say the data are missing or have not been properly analyzed...
Even acknowledging the lack of data, however, researchers like Dr. Scott Grundy of the University of Texas Southwestern Medical Center in Dallas have long argued that statins should be prescribed to women at moderately high risk for heart disease. Grundy says the underrepresentation of women in drug trials does not discount statins' benefit; it results only in a failure to show a statistically significant effect. Grundy was one of the authors of the 2001 national guidelines for lowering cholesterol and the 2004 revisions that greatly expanded the use of statins - and were criticized because of his and other authors' ties...
...Jupiter TrialGrundy says he now has the evidence he's been waiting for. In a paper published in February in the journal Circulation, researchers analyzed data on women who took part in the Jupiter trial, a large, industry-funded study that sought to compare the effectiveness of the statin Crestor (rosuvastatin) with that of a placebo in healthy patients. The study, which ended in 2008, involved nearly 18,000 participants - including 6,801 women, more than in any previous statin trial - who had high levels of C-reactive protein, a risk factor for heart disease, but did not have high...