Word: dby
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...sulfonylureas promote the release of insulin-at least in the early stages of treatment-and thus help to make fat. They recommend sulfonylureas for patients whose weight problems are not critical and for the few who are underweight. For the overweight, they prescribe phenformin (U.S. Vitamin Corp.'s DBI), which, they say, helps both to control appetite and to speed the metabolism of blood sugar...
...biguanides, the Joslin Clinic's Dr. Leo P. Krall conceded (after trial in 244 patients) that they "are capricious unless the physician uses them with special understanding." But he insisted that DBI, given along with reduced doses of insulin, has helped some unstable diabetics to lead a more normal life than they could when they took insulin several times a day. Main trouble: there is a narrow margin of safety between the DBI dose needed to control the blood sugar level and the dose that may produce side effects, so treatment in severe cases should begin in a hospital...
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