Word: dby
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Dates: during 1950-1959
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...biguanides, the Joslin Clinic's Dr. Leo P. Krall conceded (after trial in 244 patients) that they "are capricious unless the physician uses them with special understanding." But he insisted that DBI, given along with reduced doses of insulin, has helped some unstable diabetics to lead a more normal life than they could when they took insulin several times a day. Main trouble: there is a narrow margin of safety between the DBI dose needed to control the blood sugar level and the dose that may produce side effects, so treatment in severe cases should begin in a hospital...
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