Word: ddi
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...earn a B, and the bottom 10% earn a C--and a send-off if they don't improve. Such "rank and yank" systems gained popularity in the 1990s, and about a third of companies now use them, up from 13% in 1997, according to the consulting firm DDI. "Of course, you don't want to make the B's feel bad, but you also want to instill a philosophy of continual improvement," says Noel Tichy, a management professor at the University of Michigan and a GE alumnus...
Pharmaceutical companies insist the high prices are necessary to finance new-drug development. That's certainly true, at least initially. Yet many of the recent breakthroughs have been paid for by U.S. taxpayers. AZT was discovered by the National Cancer Institute and given to Burroughs Wellcome (now Glaxo Wellcome). DDI was developed at the National Institutes of Health and licensed to Bristol-Myers Squibb...
Currently, one major class of drugs that fights AIDS, called RT inhibitors, tries to interfere with RT. These drugs range from AZT to DDI...
...original anti-HIV drug and still the most widely prescribed. Unfortunately, AZT by itself is only marginally effective. The virus is notoriously changeable. Within 18 months, it usually manages to mutate into a form that is no longer susceptible to AZT or any of its chemical cousins: ddI...
...writer Christine Gorman. "It is not a cure, but it is clearly a way for people stay alive longer. Scientists are finding that combining drugs is a very effective way to treat some very serious diseases, like AIDS and cancer." The treatment, which combines the drugs AZT and either DDI or DDC, was tested on some 3,000 patients in Europe and Australia...