Word: ddi
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Didanosine (DDI) is currently being used for patients who have developed AZT resistance, Hirsch said patients, Lederking defended the study's focus...
...DDI is not as effective as AZT, which is still the most widely-used treatment, Lederking said...
Drugs such as AZT and ddI offer some temporary firepower against the HIV virus. In February, a medical student at Massachusetts General Hospital in Boston reported that adding a third drug, pyridinone, to the medicinal fusillade obliterates the virus, but that test-tube result remains to be duplicated in humans. Most of the progress has come from the prevention and treatment of the dangerous secondary infections that are the hallmark of AIDS...
Operating alone, each of the three drugs -- AZT, ddI and pyridinone -- merely slows down the virus' ability to reproduce. Eventually, the microbe mutates and becomes resistant to treatment. Chow's triple combo, however, appears to overwhelm HIV's ability to develop into new strains. More than a month after the scientists stopped treatment of their laboratory cultures, they could find no virus...
...when they combined AZT, ddI and another reverse transcriptase inhibitor, pyridinone, the virus could no longer replicate and infect other cells...