Word: ddi
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...ddI, common anti-AIDS drugs approved by the FDA, can become ineffective because of the virus' capacity to mutate to forms not susceptible to the drugs...
Chow and his colleagues found that AZT and ddI, added separately, caused the virus to mutate to different forms, but did little to halt its function...
...only other anti-HIV drugs approved in the U.S. -- DDI and DDC -- are variations on the AZT theme. Researchers have begun examining other types, however. One variety targets the gene that codes for another enzyme, protease, that is crucial to the manufacturing of viral proteins. The research looks promising, but a breakthrough is not expected anytime soon...
Groopman has researched drugs such as AZT, which treats the HIV infection; GM-CSF, which helps restore patients' immune systems; and the recently-approved DDI, which appears to help control the HIV infection...
...year for the treatment. Bristol-Myers says, however, that it will continue to offer free pills to those who cannot afford the drug or obtain insurance coverage. Another worry is side effects, including inflammation of the pancreas, numbness in the hands and feet, and diarrhea. Most important, DDI has yet to pass the rigorous testing usually required by the FDA. "We are giving DDI a status it has not earned, and we are lowering the scientific standards for drug approval," complains Dr. Deborah Cotton of Harvard, who reviewed the DDI approval application. FDA chief David Kessler justifies the decision...