Word: deacons
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...virus that the donor contracted and then passed on, the team reported last week in Science, contains flaws in its genetic script that appear to have rendered it innocuous. "Not only have the recipients and the donor not progressed to disease for 15 years," marvels molecular biologist Nicholas Deacon of Australia's Macfarlane Burnet Centre for Medical Research, "but the prediction is that they never will." Deacon speculates that this "wimpy" HIV may even be a natural inoculant that protects its carriers against more virulent strains of the virus, much as infection with cowpox warded off smallpox in 18th century...
...very least, the nef gene offers an attractive target for drug developers. If its activity can be blocked, suggests Deacon, researchers might be able to hold the progression of disease at bay, even in people who have developed full-blown AIDS. The need for better AIDS-fighting drugs was underscored last week by the actions of a U.S. Food and Drug Administration advisory panel, which recommended speedy approval of two new AIDS drugs, including the first of a new class of compounds called protease inhibitors. Although FDA commissioner David Kessler was quick to praise the new drugs, neither medication...
What scientists really want is a vaccine that can prevent infection altogether. And that's what makes the Sydney virus so promising--and so controversial. Could HIV itself, stripped of nef and adjacent sections of genetic material, provide the basis for such a vaccine, as Deacon and his colleagues cautiously suggest? Ongoing work on SIV, the simian immunodeficiency virus that causes an AIDS-like illness in monkeys, indicates that this might be less farfetched than it sounds. Ronald Desrosiers at the New England Regional Primate Research Center has demonstrated that when the nef gene is removed from SIV, the virus...
...MARCUS CHENAULT JR., 44, convicted murderer of Martin Luther King Jr.'s mother Alberta; after a stroke; in Riverdale, Georgia. On a Sunday in June 1974, Chenault rose from the front pew of Atlanta's Ebenezer Baptist Church and fatally shot the 69-year-old Mrs. King and church deacon Edward Boykin. Condemned to death, he was resentenced to life imprisonment, in part because the King family opposes capital punishment...
...postgreenhouse future. The ice caps have melted, and the world is a vast briny sea. Most people live in giant docking stations, atolls, built on water. Prowling the sea like Poseidon's angels are the Smokers, bad guys led by the one-eyed Deacon (Dennis Hopper). The Smokers are looking for Enola (Tina Majorino), a 10-year-old with a map tattoo that may point the way to dry land. With her guardian Helen (Jeanne Tripplehorn), the girl hitches a ride on the trimaran of an outsider--part man, part fish--known as the Mariner (Costner). If anyone in this...