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...drugs provided relief to 60% to 80% of patients, but they also caused serious side effects, including sluggishness, weight gain and occasionally death from overdose. The ground was ripe for a better pill, and it wasn't long before scientists produced a new, highly targeted class of antidepressants, led by Prozac, which hit the U.S. market in 1987, followed by Zoloft in 1991 and Paxil in 1992. Instead of blanketing a broad range of brain chemicals, the drugs - known as selective serotonin reuptake inhibitors (SSRIs) - zeroed in on one: serotonin, a critical compound that ferries signals between nerve cells. SSRIs...

Author: /time Magazine | Title: Antidepressants | 1/7/2010 | See Source »

...willing to reach out across the aisle. The punishment for such comity is tea-party declarations of being a traitor: witness Lindsey Graham's second censure this week by a South Carolina County Republican Party for his bipartisan work on climate change. On the Democratic side, the death of Massachusetts' Ted Kennedy, the retirement of John Breaux of Louisiana and the loss of South Dakota's Tom Daschle, along with the bitter wounds from years of being in the minority, has left the party less open to cooperation. "The Senate is a nasty and brutish place now compared to anything...

Author: /time Magazine | Title: Senate Retirements Point to Dems' Uphill Election Fight | 1/7/2010 | See Source »

...seemingly trusted agent, switch sides? The Jordanian intelligence sources who spoke to TIME speculate that al-Balawi had become enraged at the Americans for killing a high number of civilians in their hunt for al-Qaeda and Taliban leaders. And al-Balawi, who felt partly responsible for these deaths because of his role in pointing out the targeted villages in which al-Qaeda militants had been hiding, may have been consumed by guilt. "It's very possible that he decided to take revenge for the death of these Muslim civilians," says a senior Jordanian official. (See pictures of the battle...

Author: /time Magazine | Title: CIA Bomber Was No Double Agent, Say Jordanians | 1/7/2010 | See Source »

...year after the murder of the prominent Sri Lankan editor Lasantha Wickrematunge, the island's independent media is still under siege. An investigation into Wickrematunge's death has gone nowhere, and at least half a dozen other journalists, including his widow, have left the country in fear since his death...

Author: /time Magazine | Title: Sri Lanka Journalists Still on Edge After Editor's Death | 1/7/2010 | See Source »

...Since then there has been no real breakthrough, though the investigation has been taken over by the Criminal Investigation Department. There have been no arrests so far, nor are there any suspects. Journalists from Sri Lanka's minority Tamil ethnic community have long felt under threat, but Wickrematunge's death sent a clear signal that even journalists from the majority Sinhala community, like Wickrematunge, were not safe...

Author: /time Magazine | Title: Sri Lanka Journalists Still on Edge After Editor's Death | 1/7/2010 | See Source »

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