Word: defectives
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Dates: during 1990-1999
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After a frantic search lasting more than a decade, Harvard Medical School researchers will report this week that they have located the elusive genetic defect responsible for Huntington's disease...
...cells and tissues that marks the growth of an embryo is one of nature's most exquisitely orchestrated movements. And, for vertebrates, the formation of the spinal cord and brain from a simple tube of cells is as crucial to life as it is beautiful to contemplate. But any defect in this neural tube, likely to appear early in development, can be devastating. Among the possible results: anencephaly, in which a baby is born minus most of its brain, and spina bifida...
...latest issue of the New England Journal of Medicine, a team of researchers from Hungary report that women who consume 0.8 mg of folic acid, a B vitamin, for at least a month before they conceive have a dramatically lower risk of bearing a child with a neural-tube defect. Although the link between folic acid and neural-tube defects has been made before, this landmark study of 4,156 women is the first to show that the malformation can be prevented -- even in women who have no previous history of bearing children with neural- tube defects...
...group of Harvard Medical School researchers is getting closer each month to discovering the genetic defect responsible for Huntington's disease...
...paper appearing today in an Oxford University journal, Assistant Professor of Neurology Marcy E. MacDonald and Professor of Genetics James F. Gusella reported that a DNA sequence within the general location of the Huntington's defect encodes an enzyme similar in structure to those involved in brain cell communication...