Word: dicoumarin
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While physicians were learning to make the best use of heparin, Agriculturist Karl Paul Link and fellow researchers at the University of Wisconsin discovered another potent anticoagulant, dicoumarin, in rotted sweet clover (TIME, Feb. 14, 1944), which had been killing cattle. It is still widely used for long-term treatment of thrombosis patients, because it can be given handily by mouth. But the Wisconsin labs have synthesized more than 100 related substances, and one of these, Link suggested, would make a safe and deadly rat poison. He was right. Named warfarin,* it is usually applied to bait grain. Unsuspecting rats...
Best Testimonial. Physicians who had no objection to using a drug made from rotted clover that killed cattle were more wary of one touted as a rat poison. But warfarin, believes Chemist Link, is the best anticoagulant now available: it can be used in smaller doses than dicoumarin; it can be given by mouth, by injection or rectally. It works fairly rapidly, and an overdose can be promptly canceled with a form of vitamin K. Best testimonial to its safety: Chemist Link disclosed that warfarin is the anticoagulant (unnamed by Press Secretary James Hagerty) that President Eisenhower has been taking...
...suffered while shaving could cause dangerous bleeding. The President's doctors make frequent tests, make sure that his blood still has a safe margin of clotting power. He was taking pills daily, now takes them only when tests indicate that it is necessary. The drug is derived from dicoumarin...
...Biochemist Karl Paul Link, 54, University of Wisconsin, discoverer of dicoumarin, an anti-clotting drug, for fundamental contributions to knowledge of bloodclotting...
...Dicoumarin, just as effective as heparin, is far cheaper and may be given by mouth. Dr. Silbert predicted that dicoumarin will soon be used not only as a cure for thrombi, but as a routine preventive in all major operations and confinements. At present it is used in the Mayo Clinic, the University of Wisconsin, and by Drs. Irving Sherwood Wright and Andrew Gabriel Prandoni of Columbia, who made a technical report on it last fortnight...