Word: die
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Dates: during 1990-1999
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Students' reaction marked a deep shift from undergraduate opinion of Nixon when he was president 20 years ago. To baby boomers who attended Harvard, Nixon was the focus of hatred--the president who played political dirty tricks and sent their friends to die in Vietnam...
Normal cells do not live forever. Under certain circumstances, cells are actually programmed to die. One of the most fascinating features of early development, for example, is the explosive proliferation of certain types of cells, followed by mass suicide. Human embryos start with paddles for hands; it is cell death that gives them fingers. Neurons also expire by the billions as the brain refines its circuitry during development. In adults, the cell- death program serves as a stern disciplinarian. Cells that become irreparably damaged are expected to fall on their swords for the greater good of the organism...
...serious to be patched, p53 activates other genes that cause the cell to self-destruct. Mutations in p53, which have been detected in more than 50% of all human cancers, are thus extremely dangerous. In laboratory cultures, some cancer cells that possess mutant versions of p53 do not die when challenged by antitumor agents, while those that have normal p53 genes go belly...
...leave from McMaster University to work at Geron Corp. in Menlo Park, California. The company is trying to craft a drug that will block the action of telomerase. "The cancer cell," explains Harley, "is already very old. If we can inhibit telomerase, we might cause the tumor to die after a few doublings." Even better, the fact that cancer cells produce telomerase and that normal cells (save for sperm) don't, says Harley, "gives us hope that we may be able to develop a drug without serious side effects...
Today more than 1,000 Americans are murdered on the job every year, 32% more than the annual average in the '80s. Increasingly, too, they die not at the hands of strangers but because their spouses or jilted lovers pursue their quarry to the work site, or because disgruntled co-workers or customers want to settle a score...