Word: digitoxin
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Dates: during 1960-1969
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...being emphasized by a growing body of biochemical knowledge. "As a patient's health changes, or as other drugs are used," says Kalman, "the blood level of an important drug may change." One example is the use of barbiturates in combination with digitalis. If a patient is on digitoxin, one of the digitalis products, and then uses barbiturates for a while, his heart-medicine dosage should be checked, and possibly adjusted, twice. Barbiturates speed up the metabolism of digitalis-type drugs, which are critical within a narrow range. Even a modest overdose may precipitate a dangerous, abnormal heart rhythm...
...tranquilizers chlordiazepoxide and diazepam (Librium and Valium) to the list as causing breaks in animal cells, though this effect has not yet been confirmed in human patients. The antibiotics have not been shown to cause breaks, except for two compounds used only for advanced cancer. But the heart stimulant digitoxin causes breaks, said Buffalo's Dr. Maimon M. Cohen...
...Digitoxin...
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