Word: dinitrophenol
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...popular with some physicians, should not be; it can do grave harm, and there is no reason for giving it, since an underactive thyroid is very rarely the cause of obesity. Also sharply condemned: other hormones, such as pituitary extract (they have nothing to do with overweight), laxatives and dinitrophenol (it raises the temperature so that "the obese are literally frying in their own fat," and it causes cataracts...
...following notable drugs may poison the marrow in the bones, decrease the production of white blood cells, may cause death, and should be taken as medicine only with specific instructions from a well-informed doctor, said Dr. Roy Rack-ford Kracke, Atlanta blood specialist: amidopyrine, dinitrophenol, novaldin, antipyrine, sulfanilamide, sedormid, salvarsan...
...pathologist, has on at least one previous occasion nearly scorched his editorial nose by prematurely poking it into news of chemical drugs. It will be a long time before he forgets publishing in his Journal a hasty report by Drs. Cutting & Tainter of San Francisco that dinitrophenol was a useful drug for fat people to take to reduce weight speedily. Dinitrophenol does reduce weight. But as Dr. Fishbein warily editorialized, ". . . it is a two-edged sword with appalling possibilities for harm as well as for good." It was soon found that dinitrophenol also causes cataracts, scarcity of white blood cells...
...Like dinitrophenol, Prontosil is an aro matic coal tar product. Prontosil's full chemical formula is the disodium salt of 4-sulph-amido-phenyl-2-azo-7-acetylamino-1-hydroxynaphthalene 3.6-disulfonic acid. All doctors fear new drugs derived from coal tar. They may exhibit unexpected deadliness. In the case of Prontosil, since like dinitrophenol it affects the production of white blood cells, it comes under the medical rule of thumb: what ever stimulates may also destroy. And it may be that the new drug by which Dr. Tobey cured Franklin Roosevelt Jr.'s septic sore throat...
Besides cataracts, dinitrophenol depletes white corpuscles of the blood, causes polyneuritis, is responsible for seven known deaths. Last week in the American Medical Association Journal two Cleveland physicians declared it may also cause heart disease...