Word: dinitrophenol
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Dates: during 1933-1933
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...quantity of dinitrophenol five one-millionths of a person's weight (seven grains for a 200-lb. man or woman) increased a person's metabolism by 30%, made him half again as lively as before getting the dose. This sluggard's prodding has been kept up for three months with no ascertainable discomfort or injury to the people experimented on. An equivalent dosage of thyroid gland, another dissipator of indolence, would have made the experimentees irritable. Dinitrophenol caused no nervousness, anxiety, trembling, hunger or palpitation. It raised neither temperature, respiration nor pulse...
...grains of dinitrophenol caused profuse sweating...
...Five-grain doses, or slightly less reduced fat men and women two pounds a week without exercise or diet, made them feel better and more active. The investigators suggest that this dinitrophenol dose be tried cautiously for myxedema and other phenomena of sub-functioning thyroids...
...fact that dinitrophenol burns sugar and starch in healthy animals suggests that it should be good for diabetics, who do not handle their sugar and starch properly. But, strangely, diabetic dogs were easily poisoned by dinitrophenol...
...effects of dinitrophenol have not been tried on sick people, because the San Francisco investigators have not yet probed all its pharmacological repercussions. Investigators Cutting and Tainter begged last week that, "for the present, dinitrophenol be used only as an experimental therapeutic procedure in carefully selected patients under close observation by the physician...