Word: dirienzo
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Assistant Professor of Biostatistics Gregory DiRienzo and colleagues recently identified specific regions in the HIV genome which allow the virus to resist certain drugs...
...DiRienzo said he worked to uncover the link between mutations in the protease-coding region of HIV, and their ability to resist protease-inhibitor antiretroviral drugs...
...DiRienzo said in order to conduct the study he had to devise a new non-parametric method for analyzing data...
Normally, ordered data values may be parameterized, establishing a relationship between genotype and phenotype. However, according to DiRienzo, with the HIV drug resistance genotype, not only are amino acid values unordered, but there are almost an infinitessimal number of possible combinations of amino acids and thus an even higher number of possible genotype patterns. Thus, the only practical way of analyzing the data is through non-parametric methods...
...Patients with these patterns should thus be taking drugs other than amprenavir, and possibly, drugs not in the protease inhibitor class—rather, nucleoside or non-nucleoside reverse transcriptase inhibitors or the new class of drugs called fusion inhibitors,” said DiRienzo...