Word: dna
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Dates: during 2000-2009
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...FRANCIS CRICK SOLVE THE STRUCTURE OF DNA BEFORE ANYONE ELSE...
...deserve it, for a number of reasons. First, we thought it was the most important problem around. Others didn't realize that. Second, most people thought it couldn't be solved by building models--they thought you needed to get the answer primarily from X-ray crystallography of DNA. Rosalind Franklin's made that mistake. But we said, "It worked for Linus Pauling when he solved the structure of the alpha helix, so why not for us?" Third, we had each other. It helps to have someone else to take over the thinking when you get frustrated. Fourth, we were...
Almost total silence. The number of references to the original papers was essentially zero until the 1960s. People waited for the explanation of how DNA duplicated itself and how its code was turned into proteins before they fully accepted our structure. They didn't understand that it was simply too good not to be true. That's one reason we didn't get the Nobel for nine years...
...think it's safe to say we will have individualized, preventive medical care based on our own predicted risk of disease as assessed by looking at our DNA. By then each of us will have had our genomes sequenced because it will cost less than $100 to do that. And this information will be part of our medical record. Because we will still get sick, we'll still need drugs, but these will be tailored to our individual needs. They'll be based on a new breed of designer drugs with very high efficacy and very low toxicity, many...
...plan to offer some fascinating answers in a special issue the week of March 23 in which we'll profile 80 Days That Changed the World. Some had protagonists who would become famous, as in the case of James Watson and Francis Crick, who figured out the structure of DNA, an event celebrated in this issue, but we have identified some consequential days that may take you by surprise, like the Saturday in 1980 when accountant Ted Benna found an important opportunity in an obscure tax-code section called...