Word: donepezil
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Ritalin-type drugs, which have a broadly stimulating effect on the nervous system, clearly improve attention and memory. According to a 2002 study of helicopter pilots operating flight simulators, so does donepezil, a drug that raises levels of the neurotransmitter acetylcholine. In another study, men on 200 mg of modafinil did better at mentally challenging games than subjects taking a placebo. But those results must be kept in perspective. Research at the Walter Reed Army Institute of Research in Silver Spring, Md., found that neither modafinil nor the military pilots' go pills were any better than several cups of coffee...
...BRAIN BOOSTERS Some drugs for treating Alzheimer's disease increase the levels of the neurotransmitter acetylcholine, which plays a key role in attention and memory. One of the drugs, donepezil, was shown in a study of helicopter pilots to enhance mental performance. These drugs, however, are not widely abused...
Derived from the Chinese club moss, huperzine A works like donepezil and galantamine. But there is no evidence it helps young, healthy brains work better...
COMBINATION THERAPY A yearlong study of more than 400 Alzheimer's patients showed that two drugs that work differently on the brain's chemistry act well together to help slow down the disease. Patients who were being treated with donepezil (sold as Aricept), an older drug that preserves the neurotransmitter acetylcholine, were also given memantine (Namenda), a new drug approved by the FDA last October that blocks overproduction of a harmful brain chemical called glutamate. The two drugs worked even better in combination than they did alone, providing substantial benefit for patients with moderate to severe Alzheimer's, according...
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