Word: dose
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Dates: during 1940-1949
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Caumsett Spitfire was dying of pneumonia. He had a 105.5° fever, a racking cough shook his 800-pound frame. Despite huge doses of sulfanilamide and an oxygen tent, he grew steadily weaker. Then Spitfire, a purebred Guernsey bull, achieved a measure of immortality-he became the first animal (outside a laboratory) to be treated with penicillin. WPB, which now has plentiful supplies for all serious cases, let his veterinarian have 2,500,000 units (normal human dose: 1,000,000 units). At week's end, the news from Hardwick, Mass. was better: after a few gigantic shots, Spitfire...
...Streptothricin can kill a mouse, but many times the therapeutic dose is required...
...Streptothricin protects mice against 10,000 times the ordinary lethal dose of Salmonella schottmülleri (paratyphoid fever organism), Escherichia coli (colon bacillus) and Bacterium shigae (cause of Shiga dysentery). The drug's usefulness against typhoid bacteria has not yet been tested in mice, but it is effective against test-tube typhoid...
...patient is given increasing doses of insulin each day until a day arrives when he goes into a coma. On succeeding days, he gets the same dose or slightly less, with the object of keeping him under about three hours. He is brought out by a sugary drink or injection, after which he has a psychiatric interview and a big, late breakfast...
Human tuberculosis germs treated with the mold were injected in 24 guinea pigs. Six died of T.B. The other 18 did not contract the disease, although an equal dose of the germs, not treated with the mold, was almost 100% fatal to a group of control animals...