Word: dose
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Dates: during 2000-2009
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...been made public. The FDA based its decision on phase II "efficacy" data that have not yet been published. But researchers from Novartis and the Oregon Health Sciences University reported in the New England Journal of Medicine last month that 51 of 53 patients who had received the highest dose of the drug had gone into remission with only mild side effects--a little nausea, swelling and diarrhea. In seven of those cases, even the genetic abnormalities known to cause this cancer seemed to have disappeared. Doctors are testing Gleevec on an unusual stomach cancer that is triggered by similar...
...birthplace of Gabriel Garcia Marquez and many of the fables about El Dorado, has long been a land where people search for the extraordinary. So two years ago, singer-guitarist Andrea Echeverri and bassist-producer Hector Buitrago of the Colombian rock duo Aterciopelados (ah-tair-see-oh-peh-lah-dose) trekked to Colombia's Putumayo region, befriended a local shaman and joined in what Buitrago calls a healing ritual. "They make this drink, and everyone has it," says Echeverri. "You get terribly sick and get in touch with the divine part of yourself and see beautiful things...
SPLITTING HEADACHES Here's a new pick-me-up for longtime sufferers. Researchers report that a combination of low-dose tricyclic antidepressants and stress-management training can significantly reduce the severity and frequency of chronic tension headaches. The regimen is not for folks who suffer from migraines or the occasional pounder; it's for those with head pain that is severe and unremitting, occurring nearly every day for at least six months. And though the antidepressants require a prescription, they may be a better choice than aspirin, Advil or other over-the-counter pain relievers, most of which can trigger...
...thanks to technology, there is a new point of contention - the advent of the so-called "morning-after" pill, or emergency contraception, has introduced a new wrinkle in the battle over abortions. Women can take the hormone-laden pills (essentially a super-dose of regular birth control pills) up to 72 hours after intercourse to prevent an unwanted pregnancy. Depending on the stage of a woman's menstrual cycle, the pills will either keep an egg from making itself available to a sperm, or will stop a fertilized egg from implanting itself into the uterus...
Blindly assigned to one of two groups, they were given either a placebo or St. John's wort. The initial dose: three standard 300-mg tablets a day, which was upped to four tablets if there was no improvement after four weeks. Although the St. John's wort group showed slightly more improvement than the placebo group (27% v. 19%) at the end of the eight-week trial, the doctors regarded the difference as statistically insignificant. When taking prescription antidepressants, two-thirds of patients improve...