Word: dose
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...Nelfinavir, in particular, "went through the approval process very rapidly," says Dr. Mark Kline, associate professor of pediatrics at Baylor College of Medicine in Houston. "There are some basic pieces of information about nelfinavir that we don't have--like how often to give the drug or in what dose...
...flood of reports detailing how well various protease inhibitors were working on adults. "I couldn't in good conscience come back to Houston and take care of 300 kids with HIV and keep telling families that we couldn't offer protease inhibitors because we didn't know the correct dose," he remembers thinking. So Kline designed a simple study of 20 kids, ages 4 to 12, and made an educated guess at a dose that might be strong enough to do some good without doing irreparable harm. "The companies have not generated these data," he says. "I'm doing...
...successful in vanquishing HIV in adults, then pediatricians may consider using a similar approach with newborns. But they would need a lot more safety data before they could even attempt such an experiment. For one thing, babies' livers are too immature to process the powerful drugs. A full-strength dose might kill a toddler...
...what happens when that noble ideal runs up against fallible human beings. Rabe--who in the 1970s wrote big, impassioned plays about Vietnam (Streamers)--works on a much smaller canvas here. He immerses us in clinical details--like the doctor's careful instructions on how to take a fatal dose of pills (one at a time, with as little water as possible) or the compulsive conversation of the victim's lover (Stephen Spinella), who forces himself to go out to a movie when the deed is done. The narrow focus can be constricting (this is a small play...
...sprouting is quite helpful to those students needy of a quick dose of caffeine to remain awake in section. But the coffee house's corporate mega-affiliation gives cause to ask whether we are being surrounded...