Word: dose
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...runs the Jaffe Food Allergy Institute at Mount Sinai. "We start at the microgram level, scale up to milligrams and may end with grams [of peanuts]," says Sampson, but he warns people not to try the program at home. "Every patient has an adverse reaction when we increase the dose," and in severe cases, the patient may need immediate medical attention. (See how to prevent illness...
Much of the blame may fall on the Food and Drug Administration (FDA) and physician ignorance. Until 2006, FDA guidelines, which have since been revised, suggested starting pain patients on 80 mg of methadone a day - a dose that could kill people who haven't developed tolerance to this class of medications. The current recommendations call for 30 mg to start...
...while the risk of opioid addiction in the elderly is low, there are other cautions. A study published in January by Von Korff and colleagues linked high-dose opioid use to a doubling of the risk of broken bones in the elderly. "One-third of these were hip and pelvic fractures," Von Korff says. "These can really be debilitating." The authors speculate that the patients may have been prone to falls caused by dizziness or sedation, side effects of drug treatment that tend to occur early in a new drug regimen or when dosage changes...
...feelings of nurture and bonding. Saxe found that the pediatric patients in the hospital who had the most anxiety about being away from their families were also the most likely to develop PTSD, but in those treated with opioids for pain, the risk was reduced. "The pathway was opioid dose reducing separation anxiety, and reduced separation anxiety reducing PTSD," says Saxe. (See pictures of an Army town coping with PTSD...
...When he takes his turn on the hot seat on Wednesday, Akio Toyoda, the company's president and CEO - and grandson of its founder - will attempt to mollify his detractors with a heavy dose of contrition. "Toyota has, for the past few years, been expanding its business rapidly," Toyoda said in a prepared statement that he is expected to read at Wednesday's hearing. "Quite frankly, I fear the pace at which we have grown may have been too quick." He also said the company would give greater weight to customer complaints, mandate that managers drive the company's cars...