Word: dose
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...patients being treated within a Washington State health plan between 1997 and 2005. Published in the Annals of Internal Medicine in January, the study found that 51 patients had experienced overdose - six of them fatal. The overall risk of overdose was small, but it was clearly associated with the dose of the medication originally prescribed: patients receiving the highest doses were nearly nine times more likely to overdose than patients on the lowest doses. "The overall risk among people who continued to use opioids was 0.25% per year [or two overdoses per 1,000 people]," says Michael Von Korff...
Some of the overdose cases involved known drug misuse or suicide attempts, while others were due to patient error, but the study could not identify exactly what went wrong in all of the cases. Was it the high-prescribed dose alone, or were there other risk factors like illness, escalation of pain or undiagnosed addiction? While Von Korff and Volkow agree that prescription dose is a major contributor to overdose risk, they say better studies are needed to determine the precise causes and consequences. "One would hope that for a treatment regimen that millions of people are using...
...summer wears on, the work dries up. The ex-minister remains in jail. Soviet advisers hustle through the hallways. Colleagues politely cancel meetings. My parents remain calm, hoping that the new regime might tackle the poverty, illiteracy and sexism they see blighting Afghanistan. "Perhaps," says my mother, "a good dose of socialism is just what this country needs...
...high-crime hell of the 1980s and early '90s was a period of chaos in the illegal drug trade. Powder cocaine was generally measured and sold in multiple-dose amounts behind locked doors, but crack was relatively cheap and highly portable. Upstart young dealers saw an opening and shouldered their way into a business long dominated by established kingpins. Trading valuable drugs for ready cash in plain sight was a recipe for robbery and intimidation. Dealers armed themselves for protection, and soon every teenage squabble in crack territory carried a risk that bullets would...
Munger’s study—which examined the diet and vitamin D levels of more than 180,000 nurses and members of the U.S. military over several decades—found that women taking the recommended dose of vitamin D exhibited a 40 percent decreased risk of contracting multiple sclerosis...