Word: dosed
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Dates: during 2000-2009
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...Scientists first hit on zinc's effectiveness in the early 1990s, when researchers from the Johns Hopkins School of Hygiene and Public Health in Baltimore, Md., gave children in New Delhi a daily dose of syrup containing 20 mg of zinc. The rate of diarrhea dropped dramatically. "Nobody believed the results," Fontaine says. "No one had an explanation why zinc worked." Because ORT had already proved effective in the fight against diarrhea, though, aid organizations and researchers shifted their focus elsewhere - particularly to the disastrous spread of AIDS. The delay, the WHO's Fontaine says, cost the effort "at least...
...fear, ascribing near unlimited powers to the state. Life became cramped as we turned inwards on ourselves, picking up the censor's pen to scrupulously measure every word and deed. Ordinary phone calls became exercises in awkward misdirection and elision, and everyday conversations came with a healthy dose of looking over our shoulders. These were habits that I would later find difficult to shake. The movie, it seemed, would not end in Tehran, would have no final scene. (See pictures of Iran's terror in plain clothes...
Franklin is now studying the effect of baclofen on nicotine cravings. In one nine-week controlled trial involving 60 smokers, she found that those who worked up to a daily 80 mg dose of baclofen were able to reduce their smoking from 20.5 cigarettes a day to eight, a significant improvement over the placebo group, which was able to cut down to 12. And there was a distinct point at which the effect appeared to turn on - just like the switch discussed by alcoholics...
...scientists interested (the patient, a paraplegic named Edward Coleman who was taking baclofen for muscle spasms, reported that it also cut his cravings for crack), a recently published multisite trial of the drug in cocaine addicts did not produce significant results. "We think one of the reasons is the dose," says Franklin, noting that most alcoholics who have reported the switch tend not to experience it at less than 80 mg per day; the cocaine trial used...
...such prescriptions sound a little simplistic, consider this: A 2007 study by researchers at the University of Essex in England found that a daily dose of walking outside could be as effective as taking antidepressant drugs for treating mild to moderate depression. Of course, it's no secret that regular exercise is a powerful mood enhancer - although researchers noted that a similar regimen of walking in a crowded shopping mall did not have the same impact - and the boost in vitamin D production in people who spent more time outside in the sun surely helped as well...