Word: dosing
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Dates: during 1950-1959
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...body to get rid of excess water, which causes edema (dropsy) in patients with enlarged and failing hearts. Columbia University's Dr. John H. Laragh and Dr. Felix E. Demartini reported that chlorothiazide works well by itself, also increases the effectiveness of other diuretics when given in small-dose combinations. In three cases where no drug worked alone, a combination did the trick. The A.H.A.'s new president. Dr. Robert W. Wilkins of Boston University, and other researchers credited chlorothiazide with a second valuable and unexpected property: it reduces blood pressure. So far, no distressing side effects have...
...drill sessions include a fairly heavy dose of repetition of simple, everyday foreign phrases and imitation of the pronunciation of the instructor. Much of the homework consists of memorization of conversations which the students will then repeat during class. Work on grammar is done indirectly, for the most part; syntax is learned by the example of the phrases used and repeated...
...also conceded that the Services had a small supply of vaccine on hand, and that they planned to use an experimental method of injection which would spread the serum to three times as many people as could receive the customary dose...
...spread, an allergist in Philadelphia raised the possibility that greatly reduced vaccine doses can supply adequate protection if injected into the skin instead of under it. Writing in Philadelphia Medicine, Dr. Louis Tuft of Temple University reports that, on the basis of limited experiments by Walter Reed's Dr. Maurice Hilleman, one-tenth the present dose given intracutaneously produces approximately the same antibody response as the present recommended dose given subcutaneously. Suggested reason: vaccine injected into the skin is absorbed more slowly, and cells have more time to respond...
...considered safe for children, even though youngsters are more susceptible than adults to fever reactions from the shots. Recommended dosages: two shots of 0.1 cc. each, one to two weeks apart for children under five, two shots of 0.5 cc. each for children five to twelve (v. single adult dose...