Word: dosing
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Dates: during 1970-1979
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Davison's computer cell not only "grows" when it is "fed" the right diet of chemicals, but acts up when it is mistreated. In a year of testing, for instance, Davison found that when he subjected his hypothetical cell to disturbances -the mathematical equivalent of a dose of cosmic rays, say, or a virus-it usually died. Sometimes, however, the disturbances affected the chemical reactions involved in the synthesis of messenger RNA (ribonucleic acid), which carries instructions from DNA, the master molecule of heredity, to the cell's protein-producing machinery. Under these conditions, the cell began...
Some 10% to 20% of all U.S. women in the over-50 age group have some degree of hypertension, and hundreds of thousands of them are being medically treated for the condition. Most of these patients take a small daily dose of reserpine or a related alkaloid, both extracted from the roots of the Indian shrub, Rauwolfia serpentina. The rauwolfia products have been in use for 20 years, have generally been well tolerated in the dosage used by patients, and are inexpensive compared with newer medications for lowering blood pressure, such as guanethidine and methyldopa. The Boston team listed...
...committee's idea for regulating cyclamate consumption was remarkably impractical. It recommended labeling foods containing cyclamates to indicate a maximum daily safe dose of 3.5 grams for adults and 1.5 grams for children. How the committee expected cyclamate users to read a fine-print label and calculate their intake in grams...
...Communist Southeast Asia, men like Singapore's Lee Kuan Yew, the Philippines' Ferdinand Marcos and Indonesia's Suharto developed their talents during or soon after their countries achieved independence. All received a heavy dose of Western culture, and their concepts of national leadership were molded in the pattern of the imperial traditions by which they had been ruled. They were indoctrinated in character patterns thought necessary in the West to achieve supreme power in industrialized political democracies, although the traits, such as charisma or coolness under fire, have often degenerated into parody. Such leaders are less concerned with providing...
...treatment on Edward Kennedy Jr. (TIME, Dec. 3), and on 20 other patients. Methotrexate-CFR treatment is begun soon after amputation. Patients enter the hospital and receive a continuous intravenous infusion of methotrexate for six hours, during which they may be given more than 100 times the standard dose of the drug. Two hours after the methotrexate infusions are completed, the rescue effort begins. The patient is given citrovorum factor, first by injection, then by mouth every six hours for three days, while doctors monitor the patient's condition carefully and check the level of methotrexate in his blood...