Word: dosing
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Dates: during 1990-1999
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...have to approach what we are doing with a great dose of humanity," she added. "We have to make sure that we help people who are genuinely in need and that we do a lot of the other tasks that any caring village should do. We will find out how well equipped we are to do that...
...oxygen gets to the brain, triggering both unconsciousness and loss of memory. "A substance that knocks out the victim and leaves her with amnesia makes the perfect agent for date rape," says Michael Ellis, director of the Southeast Texas Poison Center. Unfortunately, as the Farias case makes clear, the dose required to knock someone out isn't much lower than the one that kills...
...York has discovered that correctly timed x-rays in the right dosage can allow severed spinal cords to partially heal, and can restore some use to paralyzed limbs. When the spinal cord is severed the limbs are paralyzed and the injury does not heal. A precisely timed dose of X-rays prevent the formation of cells called reactive astrocytes, which block the growth of damaged nerve fibers. Curiously, the rats need their dose of radiation during the third week following the injury. If the x-rays are administered later, the treatment does not work. None of the rats made...
...fact, there is more than one way to interpret the neurotoxicity research. For one thing, observes Wurtman, animals don't necessarily respond to drugs the way humans do. The toxic dose of Redux in a monkey is only twice the therapeutic dose, but the therapeutic dose in a monkey is much higher to start with--as much as 10 times that of a human. It's therefore highly unlikely, he says, that a human user would...
They found that the men have a double dose of defective copies of the CKR-5 gene. Because their T cells do not carry the CKR-5 gateway, HIV cannot gain entry, giving the men a natural immunity. No one knows if that protection is absolute, but the results, if confirmed, have broad implications for both gene and drug therapy. "What these patients apparently show is that those genes are not necessary for a person's health," says Wong-Staal. "If it's dispensable for the person but not for the virus, then it's a terrific finding. You could...