Word: dosing
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...wolf’s gullet for good either. But upon being rescued by the huntsman, Red-Cap fills the wolf’s stomach with rocks. A short epilogue relates that she kills another wolf with a wicked look in his eye with another lethal dose of stones. Victory! 3. Cinderella – This classic is far from the Disney version that’s sweet enough to give you a toothache. The wicked step-sisters’ attempts at deceiving the prince are discovered when blood leaks through the too-small shoe. As punishment for their cruelties...
Researchers at the University of Texas M.D. Anderson Cancer Center in Houston announced at the San Antonio Breast Cancer Symposium today that high-dose chemotherapy (followed by a stem-cell transplant to rebuild the immune system) after surgery does not extend the life of breast-cancer patients. The new findings, which come after a thorough analysis of 15 trials involving 6,200 patients, should close the book on a controversial treatment that was popular during the 1980s and 1990s. At the time, doctors believed that more was better when it came to chemotherapy following cancer surgery: While it was painful...
...advocates for breast-cancer patients, desperate for more and better options, pushed for access to the therapy, resulting in wrangling with some health insurers who refused to cover the treatment, saying it was too experimental. With more sophisticated cancer drugs becoming available in recent years, the demand for high-dose chemotherapy has died down, but, until now, many patients and doctors have still had questions about the usefulness of the treatment...
Despite its negative results, Berry and Norton say the study holds a valuable lesson: that perhaps more important than the size of the dose is which chemo drug the doctor decides to use. Certain cancer cells will either respond to a drug or not - so boosting the dose, particularly of the wrong drug, is not likely to make any difference in these cases. Timing may also be key - spacing apart chemotherapy doses can increase the likelihood of catching tumor cells at their weakest. Taken together, lessons like these are making a difference where it counts most - in giving breast cancer...
...Mikado” is not particularly deep or meaningful, but it is highly enjoyable and a welcome dose of sheer silly fun. It’s a perfect antidote for cold weather and late-semester papers...