Word: dosings
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...market, to public-health officials in the developing world at a loss totaling more than $253 million - not counting the millions spent on R&D. That's added up, the firm reports, to more than 550,000 lives saved. In late January, the company unveiled the first pediatric dose of Coartem - less bitter and easier to swallow than the adult version - which is expected to help in the battle against a disease that kills more than 700,000 children under 5 each year...
Almost from the get-go, however, Coartem's high $2.40-a-dose price tag was criticized by public-health officials and activists. Dr. Daniel Vasella, CEO of Novartis, says the company realized it was pointless to try to sell a medication to people who couldn't afford it. So in 2001 the company signed an agreement with the World Health Organization to bring the price down to $1 per dose, or just about the cost of making it. Then the drugmaker went one step further, slashing that price again, to 80 cents - in other words, taking a 20% loss. Meanwhile...
...proved particularly difficult. The problem lies in how to successfully monitor the supply chain while still minimizing costs, and so far, no good solution has been found. Vasella recalls visiting a Catholic mission in a Tanzanian village recently and finding that the nuns there were still paying $1 per dose. "We have all the intermediaries marking up the price dramatically," he says. "We've heard reports of some charging as high as $8 a dose to get Coartem to remote areas...
There is also the issue of drug resistance, which makes finding the next new breakthrough antimalarial all the more vital. Until that happens, Novartis hopes its new pediatric dose - which the company spent the past four years developing - is the next step toward the eventual eradication of a childhood killer...
...sports such as bungee jumping might want to use harder names." When a product like the Scirocco folds, it might have been done in not just by the nonintuitive pronunciation of the name (shi-rock-o), but also by its definiton: a hot desert wind. That's a double-dose of danger that could simply be too much for safety-conscious consumers. (See TIME's special report on the environment...