Word: doxorubicin
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Dates: during 1993-1993
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...momentum to this line of research. The monoclonal antibodies used against cancer are proteins designed to latch on to a specific molecule on the surface of a tumor cell, while leaving normal cells untouched. In Bristol-Myers Squibb's experiment, the antibody was linked with the common anticancer drug doxorubicin, and unlike many previous preparations, this combination enabled the drug to enter tumor cells, killing them from the inside...
...combination of the antibody, acting as a guidance system that homes in on tumor cells, and doxorubicin, as the lethal payload, knocked out many kinds of advanced cancer in mice, including colon, lung and breast tumors that had spread to other organs. In earlier animal experiments, researchers were able to cure only those cancers that had not been growing very long or that had not metastasized. "One of the problems that have held back the field for a long time is that we were never sure that well-established solid tumors could be eliminated," says Dr. David Scheinberg, chief...
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