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Melatonin, which is available over the counter in pill form, is a known treatment for jet lag, but the substance can't be patented, leading drug companies like Vanda Pharmaceuticals, the maker of tasimelteon, to rush to develop drugs that imitate it. Dr. Irshaad Ebrahim, medical director of the London Sleep Centre, says the recent study, published Dec. 2 in the journal The Lancet, confirms what experts already know. "I'm not sure this adds anything. Melatonin itself can be quite effective on its own. So, of course, something that mimics melatonin would show promising results," he says...
Still, a melatonin-emulator may offer some utility, Dr. Ebrahim says. Currently in the United States and many other countries, melatonin can be purchased easily as a health supplement, but supplements are unregulated and vary in quality and strength, making it difficult for consumers to receive a consistent dose...
...interim, Dr. Ebrahim says, sleep experts have developed more reliable - albeit more complicated than popping a pill - methods of altering the body's natural melatonin production, which may help some of the 100 million people who take international flights from the U.S. each year, and the millions more who live in a perpetual state of jet lag due to night-shift work. One strategy is to use light-dark exposure, which helps cue the body's circadian rhythm. British Airways, for example, offers a "jet-lag calculator" that applies research into bright-light therapy to advise passengers when...
...official statistics agencies produce are conservative estimates of probably the lowest level of child maltreatment," says Dr. Cathy Spatz Widom, a psychology professor at John Jay College of Criminal Justice, who specializes in the long-term effects of child abuse and is a lead author on one of the Lancet studies...
...experiment was borne out of the closing, in the early 1990s, of Zurich's infamous Letten "needle park," where thousands of addicts from across Europe gathered to shoot heroin on garbage-strewn railway tracks. "We wanted to offer a program to reach out to these people," says Dr. Adrian Kormann, medical director of a Zurich HAT clinic where Heun is treated. "And we knew that an approach based only on repression doesn't work...