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That distinction is largely unfamiliar both to the general public and within the medical field, yet it is a crucial one when it comes to treatment decisions for end-stage dementia patients. Dr. Greg Sachs at the Indiana University Center for Aging Research says a lack of appreciation of the nature of dementia leads to misguided and often overly aggressive end-stage treatment. Five years ago, Sachs wrote a paper on such barriers to palliative end-of-life care for dementia patients, but he ran into difficulty explaining the findings to the editors of the major medical journal that published...
...those events lead to death. Only seven patients had a major event during the final three months of life. "Our main findings confirmed dementia has high mortality. People in the study didn't have other devastating things happen to them before they died," says the study's lead author, Dr. Susan Mitchell of the Harvard-affiliated Hebrew SeniorLife Institute for Aging Research. (Read "The Year in Medicine 2008: From...
...outset, as the end result is the same, according to Mitchell's study: a syndrome of symptoms and complications - eating problems (86%), pneumonia (41%), difficulty breathing (46%), pain (39%) and fever (53%) - caused by brain failure. "Dementia ends up involving much more than just the brain," says Dr. Claudia Kawas, professor of neurology at the University of California, Irvine. "We forget the brain does everything for us - controls the heart, the lungs, the gastrointestinal tract, the metabolism...
...exists, is so tiny that it's not worth pursuing in a significant way. They also question whether such a large trial can be considered as a proof of concept. "Doing a 16,000-person trial, it can't be a proof of concept at that point," says Dr. David Ho, director of the Aaron Diamond AIDS Research Center in New York City. "Would I invest in it? The answer is no. There are other things that are more likely to work, that are better, easier and more straightforward than this vaccine...
...Aqeel, also known as Dr. Usman, was already wanted for earlier terrorist attacks. He acquired his medical nom de guerre due to his 16 years as a nurse in the army's medical corps. In 2004, he abandoned the army to join Lashkar-e-Jhangvi (LeJ), a vicious sectarian terror group from Punjab. "He knew how the army functions," says Shaukat Qadir, a retired brigadier turned analyst. "That's why he organized this attack better than others could have done." The embarrassing breach of the heavily fortified headquarters was made possible through artful disguise, military officials said. The vehicle bore...