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Williams's group collected 16,000 DNA samples from Alzheimer's patients and healthy controls, while the French team, led by Dr. Philippe Amouyel at the Pasteur Institute, gathered more than 7,000 similar samples. Each team worked independently, unaware of the other lab's research, until both happened to present their data at the International Conference on Alzheimer's Disease in Vienna in July. Williams, who was in the audience when Amouyel gave his talk, immediately checked her database on her laptop and found to her delight that her group had identified the same high-risk genes as Amouyel...
...possible that the body cannot balance these two functions of clusterin. "It may be that the difference between a variant of clusterin that protects from Alzheimer's versus one that has a higher risk is the balance between clearing amyloid versus causing it to form more deposits," says Dr. Alison Goate, an author of the U.K. study and a member of the scientific advisory board of the Alzheimer's Association...
...worried by reports that President Karzai's supporters committed widescale fraud in the Aug. 20 elections, and this, the shop-keeper says, could re-open ancient ethnic grudges between the Pashtuns, most of whom back Karzai, and the non-Pashtuns who are rallying around his main challenger, Dr. Abdullah Abdullah. (Read about the German contingent in Afghanistan...
...long time we questioned whether or not eating patterns had anything to do with gaining weight," says obesity expert Dr. Louis Aronne of NewYork-Presbyterian Hospital/Weill Cornell Medical Center. He points to previous observational research suggesting that people who skip breakfast in favor of massive meals in the evening hours tend to be overweight. "We had no proof that it's a real problem," says Aronne, who was not involved in the study. "If an experiment like this is replicated in humans, it might clarify for us just how much time of day matters when it comes to obesity...
...were injected with leptin have failed, because the metabolic pathways that control hunger and fullness in people are far more complex than they are in mice. Knocking out one of, say, 50 such pathways through drug treatment just means the other 49 will eventually pick up the slack, says Dr. George Fielding, a bariatric surgeon at the NYU Program for Surgical Weight Loss...